Knowledge Attitude Practices Repeat Cesarean Health And Social Care Essay

Knowledge Attitude Practices Repeat Cesarean Health And Social Care Essay Cesarean delivery is defined as the birth of a fetus through incisions in the abdominal wall and uterine wall . An increase of in the cesarean delivery has been observed worldwide. However, the World Health Organization (WHO) states that no region in the world is justified in having a cesarean rate greater than 10 to 15%. According to the WHO, cesarean delivery rate of more than 15% is indicative of inappropriate use of resources . According to Department of Health, the Philippines 2006 national cesarean rate is 24%. In Davao Medical Center (DMC), the rate as of 2008 is recorded at 19% as depicted in the OB-Gyne departments annual cesarean review statistics. In the US, most common indication of cesarean section is repeat cesarean which accounts for 35% of all cases as reported by the United States Public Health Service. The rates have been steadily increasing due to a higher number of sections for fetal distress as electronic fetal monitoring has been used extensively for presumed fetal compromise, the many breech presentations delivered abdominally as well as the increasing acceptability of cesarean delivery by maternal request. Before the 1970s, deliveries by cesarean section were considered as an indication for cesarean section in the subsequent pregnancies, reflecting a concern that uterine scar tissue might rupture during labor. However, in the 1980s, the dictumonce a cesarean, always a cesarean, espoused by Craigin (1916) was revised in many countries, and a trial of labor in women with history of cesarean section was proposed as an attempt to reduce cesarean section rates. However, an apparent increase in the incidence of uterine rupture and concern about maternal and fetal safety have challenged the choice of vaginal delivery in women having a scarred uterus. As a consequence, clinicians are increasingly being faced in deciding the mode of delivery in pregnant women whose first delivery was by cesarean section. This scenario has also been observed in the Philippine setting. DMC, as a specific case, recorded increasing cesarean deliveries accounting to a third of all deliveries for 2008, of which, 11.53% for repeat CS while 19.8% for primary CS. In contrast, Vaginal Birth after Cesarean Section is a measly 1.2% of the total deliveries for 2008. This is due to the fact that patients who underwent VBAC were admitted for imminent delivery. Majority of these patients were not prepared during their prenatal visits and were unaware of the complications and risks of VBAC. The confounding reason of such practice is primarily economics: the high cost of undergoing an elective CS delivery as compared with the cost of vaginal delivery. These patients would rather risk undergoing VBAC without the benefit of intrapartum monitoring specifically for those attempting to deliver at lying-in clinics or at home. Based on the National Institute of Child Health and Human Development (NICHD) study, the incidence of uterine rupture is low at .2-.7% (Landon,2006). But despite its low incidence, ACOG guidelines on VBACS specifically mentioned that VBAC be performed in an institution where an obstetric, anesthesia, pediatric, and operating-room staff is available. This scenario provided impetus for the conceptualization of this study which is aimed at determining the knowledge, attitudes, and practices of repeat C-section patients and their willingness to undergo vaginal birth after C-section at DMC. Review of Related Literature In 2004, the number of C-sections had reached an all-time high, accounting for 29% of all births or 1 million babies (National Center for Health Statistics). This is despite the convention that vaginal delivery is associated with less maternal and fetal morbidity and mortality as compared with repeat cesarean section (Chauhan, 2004). For example, observational studies data from around 90,000 deliveries, have shown an increased risk of neonatal respiratory morbidity among term infants delivered by caesarean section (3.5-3.7%) compared with vaginal birth (0.5-1.4%). The following maternal risks significantly increase with increasing number of repeated caesarean deliveries: placenta accreta, injury to bladder, bowel or ureter, ileus, the need for postoperative ventilation, intensive care unit admission, hysterectomy, blood transfusion requiring four or more units and the duration of operative time and hospital stay (Russen et. al. 2004). Moreover, authors speculated that a prolonged inter-pregnancy interval may allow time for the previous cesarean delivery scar to reach its maximal tensile strength before the scar undergoes the mechanical stress and strain with a subsequent intrauterine pregnancy (Shipp et. al., 2000). Menacker et al. (2006) noted that cesarean rates fell between 1991 and 1996, and then began to rise rapidly. In 2004, over 29% of all births were by cesarean section. The rise in both the total and repeat cesarean rate has been widespread for women of all ages, races, medical indications, and for all infant gestational ages. The study also noted steep decrease in VBAC rate from 1996 to 2004 (see Figure 1). From this trend, the authors opined that the influence of recent medical opinion discouraging VBAC has had a strong effect on practice patterns, and had led to greater uniformity as well as a large increase in repeat cesarean deliveries by 2003. Figure 1 (Source: Menacker et al. pp. 236) The dramatic increase in cesarean sections over the past two decades has been significantly driven by repeat C-sections. In response, clinical guidelines recommending vaginal birth after cesarean-section (VBACS) have been promulgated by international organizations from different countries such as the United States, Canada, Europe, New Zealand and Australia. It is construed that adherence to these guidelines would reduce the number of repeat C-sections, lower the overall C-section rate and improve both the quality and the cost of health care. While these guidelines have received professional endorsement, their implementation has been clouded by issues of patient acceptance and provider payment. Neff (2004) discussed the risks and benefits of VBAC. Successful VBAC generally is associated with shorter maternal hospitalizations, fewer infections, less blood loss and fewer transfusions, and fewer thromboembolic events than cesarean delivery. However, a failed trial of labor may be associated with major maternal complications, such as hysterectomy, uterine rupture, operative injury, increased maternal infection, need for transfusion, and neonatal morbidity. Multiple cesarean deliveries are associated with an increased risk of placenta previa and accreta. With VBAC (Landon, 2004), the incidence of maternal death is extremely low. The incidence of perinatal death is less than 1 percent, and is more likely to occur during a trial of labor than an elective repeat cesarean delivery. Uterine rupture during a trial of labor after a previous cesarean delivery is a life-threatening complication directly associated with attempted VBAC. The patients obstetric history influences the risk of uterine rupture. A previous vaginal birth significantly reduces the risk of uterine rupture. Also, the longer the length of time between deliveries, the lower the risk of rupture. Women who attempt VBAC who have interdelivery intervals of less than 24 months have a two- to three-fold increased risk of uterine rupture compared with women whose interdelivery interval is more than 24 months. A study conducted Hopkins and Potter (1998) on C-sections patients in Brazil concluded that while many women fear the pain associated with childbirth and the consequences of a vaginal birth for the baby, they do not clamor for C-section delivery. Obstetricians were observed to have overplayed these fears to their advantage thereby overly estimating safety of C-section delivery. In fact, it has become a routine practice and is considered as safe or safer than a vaginal delivery. The study further documented that majority of first-time mothers in public and private hospitals wanted to deliver vaginally and considered vaginal birth superior in terms of recuperation. A majority believed that vaginal delivery does not have effect to their or their partners sexual life. Though majority was found to have considered normal childbirth more painful than a cesarean, but most also believed a cesarean causes a lot pain after the delivery. Less than 33% agreed that a cesarean is safer for the baby and less than 20% of women agreed that a C-section is safer for the woman. Objectives of the Study The objectives of the study are twofold: To come up with a profile of the knowledge, attitudes and practices (KAPs) towards vaginal birth after C-section (VBACS) among repeat C-section patients Determine whether the KAPs of the respondents significantly influence their willingness to undergo VBACS Statement of the Problem This present study seeks answers to the following questions: What is the profile of the respondents in terms of their knowledge, attitudes and practices about VBACS? What is the frequency distribution of the respondents in terms of their willingness to undergo VBACS? Do the KAPs of the respondents significantly influence their acceptance to undergo VBAC in their next delivery? Does counseling about VBACS affect the respondents willingness to undergo vaginal birth after C-section? Conceptual framework It is hypothesized that the KAPs of the respondents toward VBAC significantly influence their willingness to deliver vaginally after having experienced C-section in their previous delivery. Significance of the Study The most common reason that a C-section is performed is that the woman has had a prior C-section delivery. DMC is not spared from the increasing trend of repeat C-section rate. Since vaginal delivery is undoubtedly associated with less maternal and fetal morbidity and mortality, not to mention, medical supplies and other hospital resources, there is a need to find ways in order to reduce repeat C-section rate in DMC. DMC, a tertiary and referral hospital in the Southern Mindanao Region, has no available data on KAPs of women towards VBACS. Thus, the range information that this investigation will generate could provide baseline information that can be used to design appropriate interventions aimed at reducing the overall C-section rate in the institution. One of which is by counseling and encouraging patients to undergo VBACS. One of the significant risks when considering VBACS is uterine rupture because it has been the belief and fear of many repeat cesarean patients that a previously scarred uterus is too weak to withstand trial of labor hence discouraging them from going into VBACS. The information that would be gathered from this study would be of help in counseling repeat C-section patients ante-nataly and post-nataly to enable them to plan their preferred spacing intervals for the subsequent pregnancies. This is because women with prior C-section birth is considered high risk and so to optimizing maternal well being and healthcare. Moreover, data about the knowledge, attitude and practices of patients who had prior CS birth on VBACS would be of help to assess the level of acceptance of these patients and hopefully allay their fears thereby coming up with the best informed choice. Lastly, the results of the investigation could spur future research in the subject VBACS. Dependent Variable The willingness of the respondents to undergo vaginal birth after cesarean section in their next delivery Independent Variables The profile of the respondents in terms of their knowledge, attitude and practices towards vaginal birth after cesarean section. MethodOLOGY Design A descriptive cross-sectional survey design would be employed to address the research questions. Setting Outpatient department of the OB clinic in Davao Medical Center Respondents and Sampling All patients who had a prior C-section birth seen at the high risk clinic of the DMC OB OPD will be included in the sampling frame from February to April 2010. The sample size will be determined using the model , where n is the sample size, N is the population size and e is the margin of error. Inclusion Criteria All patients who had a prior CS birth will be included in the study. Exclusion Criteria Patients who will not give their consent will be excluded from participating. Data Extraction The questionnaire will be pilot tested among ten patients with previous CS at the DMC OB OPD. A structured survey form will be used for gathering data about the respondents KAPs towards VBACS and their willingness to undergo vaginal delivery (see Attachment 1). The principal investigator (PI) will conduct a one-on-one administration of the survey form. Prior to gathering information pertinent to the questions in the survey, informed consent (see Attachment 2) will be secured by the PI. After data gathering, the principal investigator will counsel the respondents about VBACS, its indication and absolute contraindication, complications and the VBACS ACOG guidelines. A post-test question will be done on their willingness to undergo VBACS after being counseled. Ethical Consideration Approval from the hospital ethics committee will be sought before the study will be conducted. After thoroughly discussing the nature, methodology and objectives of the study to the respondent, a written consent will be asked from each participating patient. Data Analysis The KAPs of the respondents towards VBACS will be profiled using descriptive statistics such as the mean, standard deviation, frequency and percentage distribution. Their willingness to undergo vaginal delivery before and after counseling about VBACS will also be described using frequency and percentage distribution. Logistic regression analysis will be used to determine whether or not the KAPs of the respondents significantly influence their willingness to undergo VBACS. Time Frame The study will be conducted in February-April 2010. Budget Materials: 10,000.00 Miscellaneous: 8,000.00 Total: 18,000.00

Case Study †Catfish Dispute

â€Å"The Vietnamese catfish importers are enjoying the fruits of our work,† This was the main discontent of the domestic (US) catfish industry. Undoubtedly, the catfish farmers had put a lot of effort in improving the aquaculture technology to raise the catfish with better quality; thus, raised the demand of domestic market. At the same time, they had invested about US$50 million in the industry’s marketing. When catfish became the third favorite seafood of the American, leading to a total consumption of 275 million kilograms in 2000, it inevitably attracted people to get in the market.However, based on the fact that the US Congress had approved the U. S. -Vietnam Bilateral Trade Agreement (BTA) with a reduction in tariff, it was the right for American importers to start the new business – importing Vietnamese catfish. The agreement was approved by the Congress due to the important reason: the trade benefits. To capture these benefits, they had to undertake the possible risks. Indeed, it was a fair game played by both parties. From the article, it was clear that one of the sources of discontent from domestic farmers was the quality considerations difference between the American-grew and Vietnam-grew catfish.The quality of US catfish is justified by the inspection of 17 federal agencies and can meet the standard of the Catfish Institute of America, whereas the Vietnamese catfish only need to pass the Food and Drug Administration’s approval. This preferential practice should not sustain. The authority should consider standardize the quality requirement of both places’ catfish, for example, make it compulsory for Vietnamese catfish products to undergo the same inspections as the US catfish. Or at least, ask for proof of quality issued by Vietnamese government for all imported catfish.

Embryonic Stem Cell Research is Morally and Medically Ethical Essay

Introduction Issue ( Background)   Science and technology have opened many doors of progress in all areas of business.   On such area far exceeds mere business and industry and touches upon human life itself.   The medical community has reached a point where it can quite possibly create new and healthy cells and organs to replace those that are damaged.   This process is made possible through embryonic stem cell research (ESCR). Embryonic stem cells, as suggested by the name are extracted from embryos that have been fertilized in a laboratory setting for use by sterile couples and then, for whatever reason, are donated for research.   These cells are about five days old (Stem Cell Basics).   The cells are then developed and grown in a culture medium and shipped to other laboratories for further research. These stem cells are special because they can be converted through genetic manipulation to be any type of cell desired. â€Å"To generate cultures of specific types of differentiated cells—heart muscle cells, blood cells, or nerve cells, for example—scientists try to control the differentiation of embryonic stem cells. They change the chemical composition of the culture medium, alter the surface of the culture dish, or modify the cells by inserting specific genes† (Stem Cell Basics).   The benefit of this process is that these new healthy cells can be used to replace defective or diseased cells in individuals, in effect curing them of certain ailments. Conflict, c. Stance and d. Enthymeme The controversy with this particular procedure stems from the fact that extracting these cells effectively kills the developing embryo, called at this stage a zygote.   Those who believe that these cells constitute a human being, liken the process of extracting stem cells to abortion and murder (Robinson).   Those that do not believe this way see the major medical benefits as outweighing the death of an unwanted and unused zygote.   Most of the arguments against ESCR are religious in nature while those that favor it are following pragmatic and realistic processes.   In light of the medically invaluable information and hope it provides, embryonic stem cell research should legally continue with full funding from the federal government.   II. Grounds  Ã‚   Even as focus has turned toward adult stem cell research, ESCR remains the most valuable and efficient way of utilizing stem cells for medical purposes.   In 2005, the United Kingdom announced that it was considering opening a stem cell bank using embryonic stem cells.   Its research team at the University of Cambridge found that only 150 human embryos would be needed to created genetic material for approximately two-thirds of the population.   The bank hopes to use these cells to replace â€Å"diseased or damaged tissue in conditions such as diabetes and neurodegenerative disorders† (Lita). Embryonic stem cells can help treat neurological disorders such as Parkinson’s and endocrinal disorders such as diabetes.   Embryonic stem cells can be transformed into dopamine-producing neurons because these stem cells can be transformed into virtually any body cell including nerve cells and pancreatic cells.   These cells can then begin producing dopamine or insulin as the case may be. (Kennell). Victims of spinal cord injuries may soon be able to regain motor control as the result of ESCR.   Preliminary research shows that it is possible to train embryonic stem cells to retrace neuro-motor pathways.   Douglas Kerr, M.D., Ph.D. of Johns Hopkins University notes that â€Å"This is proof of the principle that we can recapture what happens in early stages of motor neuron development and use that to repair damaged nervous systems†Ã‚   (Embryonic Stem Cells Repair Latent Motor Nerve). III. Warrant Despite its proven medical capabilities and hope for many other medical uses, ESCR has found virulent opposition from conservatives and the religious community.   Their arguments hinge on the use of a living human being as fodder for medical experimentation.   These arguments are suspect, even flawed, for several reasons, both philosophical and biological. Generally speaking, the more practical and pragmatic medical argument must be valued over the religious beliefs of some. First, many will argue for the analogy between ESCR and murder.   Many differences exist.   As stated earlier, the zygote in question is only five days old.   In no way could this particular cluster of cells contain life at this point – only the potential for life, which is basically the case whenever a woman and a man have intercourse.   Lawyers from the National Institute of Health agree, noting that â€Å"stem cells are incapable of growing into a complete person. They may be coaxed to develop into nerve cells or heart cells. But, at most, they can become an organ, not a complete living person. They cannot be considered a form of human life, even within the definition of pro-life supporters† (Robinson). Doctors even give biological explanations for this conclusion:     Ã¢â‚¬Å"Human embryos are defined as human organisms derived by fertilization from one or more gametes or diploid cells. Pluripotent stem cells are specialized subpopulation of cells capable of developing into most (ectoderm, mesoderm, and ectoderm), but not all, human tissue and may be derived from human embryos†Ã‚   (Chesney).   Medically, even the cells are not the same. However, the zygotes are being stored indefinitely at in-vitro fertilization clinics.   For example, in the United States are over 350 fertility clinics that offer the in-vitro fertilization process.   When a women submits herself to the procedure, about 25 ova are removed from her body and fertilized with her husband’s (or other donor’s) sperm.   Only 2-4 of the embryos are used in the fertilization procedure and the rest are frozen in liquid nitrogen to save for later use.   Generally, these remaining 20 or so embryos stay in the clinic indefinitely.   Few couples use them all, and even fewer agree to donate them to other infertile couples. Many embryos die due to changes in temperature or movement, and some clinics even throw the excess embryos away or use them in training staff (Robinson).   The birth control pill blocks a fertilized ovum from implanting as does an intrauterine device (IUD).   These two devices, along with discarding the embryos or using them for training, also affect the potential for life but are not so reviled.   Moreover, the embryos’ ‘owners’ must always give consent to use these embryos for research; nobody is tricked during this process (Robinson). Basically, if these cells are not used for ESCR, they will ultimately be used for nothing. Second, many opponents argue that adult stem cell research (ASCR) could replace ESCR and save the embryos.   This is not yet the case, if it ever will be.   First of all, the nature of the stem cells are different in adults and in embryos.   Embryonic stem cells are more flexible and can become virtually any cell of any organ or tissue in the body.   Adult stem cells are much more limited and cannot even be found in many organs or tissues in the body. Moreover, adult stems cells are limited in number, even considered ‘minute’ in quantity and are very hard to identify.   Embryonic stem cells are easy to identify and exist in large, usable numbers.   Most importantly, embryonic stem cells are virtually blank, making them easy to manipulate into other tissues.   Adult stem cells can contain genetic defects or â€Å"DNA errors caused by replication or exposure to toxins† (Cohen). ESCR has been the focus of scientist for nearly two decades while ASCR has just begun to get some notice.   Because of the emergence of ASCR, the opponents want to completely ban ESCR, not understanding that it is the reason that ASCR is even possible.   However, because of the religious issues, ASCR is being forced into the limelight while ESCR has lost funding. As a result, Dr. Helen Blau, ironically an adult stem cell researcher at the Stanford University, argues that she feels â€Å"strongly we need embryonic stem cells. The answers are not just going to come from the adult stem cells and it would be extremely short-sighted to shift completely to just adult stem cells† (Cohen).   While adult stem cells may provide promise in the future, their use in the present is simply not as lucrative or promising as those of embryonic stem cells at this point in time. Backing and V. Conditions of rebuttal Most arguments in opposition to ESCR originate in the religious realm.   Dr. Dr. David Prentice,   professor of life sciences at Indiana State University and founder of Do No Harm, The Coalition of Americans for Research Ethics notes precisely this when he asserts, â€Å"The root of the debate really comes down to the ethical question of what’s the moral status of a human embryo.   Is it a person or is it a piece of property? And obviously we have no consensus on that in this country and I think that means we should not use taxpayer funds to fund this type of research†Ã‚   (Cohen). Yet, historically, this religious realm, when mixed with federal forces, has been squelched in other instances.   For example, removing the ten commandments from federal buildings, denying prayer in school, and eliminate swearing under God to affirming under oath in courtroom proceedings are just a few of the ways that the government has attempted to separate the church and the state.   Why is the religious conservative view allowed to proliferate here when it is not allowed to do so in other instances? Similarly, the force of this religious surge against ESCR is the loss of life.   While the beginning moment of human life is hugely debatable, does ESCR not also promote life?   Lawyers and medical ethicists in favor of ESCR note that â€Å"Stem cells have an enormous promise to benefit mankind — to save lives and cure or treat diseases. This generates a very strong moral imperative to explore their potential† (Robinson). Similarly, the conservative and religious opposition seems to even contradict their own opinion by not voicing concern about in-vitro fertilization clinics in general.   As noted above, clinics routinely destroy abandoned embryos by flushing them down drains, incinerating them, or exposing them to room temperature†Ã‚   (Hall).   Basically, unused, destroyed embryos number in the hundreds of thousands in fertility clinics across the country, but these clinics are not subjected to the political manipulation that ESCR is, which only uses a dozen or two embryos in the clinical setting. Furthermore, the â€Å"parents† of these embryos are never challenged.   The donors get to decide the fate of their unused embryos.   The choices are to leave them to the use of the clinic, to donate them or to destroy them.   Dr. Carl Herbert, president of the San Francisco Fertility Centers, notes that while this loss may seem harsh, it simply mimics the natural reproductive cycle. He points out that Out of all the embryos created by sexual intercourse, roughly 3 out of 4 do not last long enough to produce a baby. About half of the fertilized eggs are lost even before the woman misses her first period following conception† (Hall).   Dr. Marcelle Cedars, a fertility specialist at the University of California at San Francisco’s IVF clinic agrees.   He argues that it is â€Å"unrealistic to expect technology to do much better at preserving the lives of early-stage embryos. Human reproduction is a very inefficient process and it is difficult to afford a higher status to embryos than nature does† (Hall). Qualifier Of course nobody wants to believe that a promising medical science field could be corrupt or greedy.   Even ESCR should operate under certain moral guidelines. In no way should an embryo ever be used in any way except by that to which its donor consents.   In addition, donors should not create embryos for the sheer purpose to sell them to clinics, as the process should result as a by-product of extra embryos create for potential implantation and not create any additional embryos not for that purpose.   Finally, tricking or deceiving individuals into donating embryos or withholding information about their use would also be morally wrong. VII. Conclusion ESCR is not the enemy of the moral fiber of the United States.   It is a medically promising procedure that does not violate any right to life laws.   Religious opposition to certain issues will always exist, but in recent history, it has not been allowed in interfere with federal political, social or educational decision-making.   Clearly other possibilities and alternatives to ESCR may arise, but until these options are as viable as ESCR, they should not be allowed to interfere with the medical promise of this type of research. Works Cited Chesney, Russell et al. American Academy of Pediatrics, Human Embryo Research Committee   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   on Pediatric Research and Committee on Bioethics.   Pediatrics 108 (3), 3 Sept. 2001:     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   813-816.   Retrieved 1 April 2008 from   http://aappolicy.aappublications.org/cgi/content/ full/pediatrics;108/3/813 Cohen, Elizabeth.   Adult stem cells or embryonic? Scientists differ.   CNN.com/Health.   10   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   August 2001.     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Retrieved 1 April 2008 from http://archives.cnn.com/2001/HEALTH/ 08/09/stem.cell.alternative/ Embryonic Stem Cells Repair Latent Motor Nerve.   Science Daily. 28 June 2006. Retrieved 1   Ã‚   April 2008 from http://stemcell.taragana.net/archive/embryonic-stem-cells-repair-latent-  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   motor-nerve/ Hall, Carl T. â€Å"The forgotten embryo: Fertility clinics must store or destroy the surplus that is part   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   of the process.†   SF Gate News.   20 Aug. 2001. at: http://www.sfgate.com/ Kennell, David.   The promise of stem cell research. People’s Weekly World Newspapers.   29   Ã‚   July 2006.   Retrieved 1 April 2006 from http://www.pww.org/article/articleview/9582/1/332 Lita, Ana.   Embryonic Stem Cell Research: New Developments and Controversies.   MedBioWorld.   Ã‚  Ã‚  Ã‚   10 October 2006.   Retrieved 1 April 2008 from http://www.medbioworld.com/ postgenomics_blog/?p=138 Robinson, B.A. Human Stem Cells – Ethical Concerns.   Religious Tolerance.   17 Oct. 2002.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Retrieved 1 April 2008 from http://www.religioustolerance.org/res_stem2.htm   Ã¢â‚¬Å"Stem Cell Basics.†Ã‚   The National Institutes of Health.   20 Feb. 2008.   Retrieved 1 April 2008 from http://stemcells.nih.gov/info/basics/basics3.asp

Preparation of Aspirin and Determination of the Melting Point

PREPARATION OF ASPIRIN AND DETERMINATION OF THE MELTING POINT Ferrer, Lara Melissa V. Faculty of Engineering University of Santo Tomas Manila, Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin, isolation and purification, and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4. When the aspirin was prepared, it was isolated and filtered. The percentage yield of the synthesis was calculated to be 78.42%. The experimental melting point range of aspirin was determined to be 122 -132 °C. Due to its wide range, and lower value than that of the theoretical melting point of 136 °C, it was†¦show more content†¦Salicylic acid is also used in a variety of other personal care items such as dandruff shampoo, antiseptic and toothpaste. [2] METHODOLOGY 3.0g of salicylic acid was weighed then 3.0mL of acetic anhydride and 6 drops of 85% H3PO4 were added to it. The mixture was warmed over a water bath for 5 minutes while stirring. After warming, 20 drops of distilled water was slowly added. 15mL of water was added then the solution was heated until it became clear. It was allowed to cool and was placed in an ice bath until the solution becomes cloudy. Using pre-weighed filter paper, the mixture was filtered and was allowed to dry in the filter paper. In determining the melting point range of the aspirin, a capillary tube (sealed at one end) was one-third-filled with the dried aspirin. The capillary tube and a thermometer were immersed in an oil bath. The temperature at which the solid started to melt and the temperature when the entire sample was completely liquefied were recorded as the melting point temperature range. 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